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Prescribing Information
Important Safety Information
For Patients

Greater Lubrication and Superior Friction Reduction3*

HYMOVIS® ONE is a true viscoelastic hydrogel – its unique molecular structure significantly

improved lubrication, reducing friction on cartilage in a preclinical analysis3*

HA effects of friction reduction on cartilage at various sliding speeds*

Line chart: friction coefficient vs sliding speed for PBS, Monovisc, Synvisc, and Hymovis, showing Hymovis with the lowest friction coefficient (about 0.05-0.06) across sliding speeds from 0.1 to 100 mm/s

Sliding Speed (mm/s)

*Preclinical test data may not be indicative of human clinical outcomes.
Several hyaluronan (HA) viscosupplement products were assessed in this preclinical analysis. This graph demonstrates
preclinical comparison of selected single-injection HA viscosupplements.
The molecule of HYMOVIS® is the same as HYMOVIS® ONE. The molecule of Synvisc® is the same as Synvisc® One.
Third-party trademarks used herein are trademarks of their respective owners
PBS = Phosphate buffered saline

In a pre-clinical study

HYMOVIS® ONE demonstrated greater recovery of molecular structure (elasticity) under repeated mechanical stress4*

Bar chart: percent recovery of molecular structure after repeated mechanical stress, comparing Hymovis at 88%, Synvisc at 71%, and Durolane at 43%

*Preclinical test data may not be indicative of human clinical outcomes.
The molecule of HYMOVIS® is the same as HYMOVIS® ONE. The molecule of Synvisc® is the same as Synvisc® One.
Third-party trademarks used herein are trademarks of their respective owners.

All 3 HAs started at a pre-stress baseline of 100% and had an instantaneous post-stress response of 29%.*


Following repeated stress, the structure of HYMOVIS® stabilizes due to the reversible hydrophobic interactions of the amide-containing alkyl side chains.*

Study design: Recovery of mechanical properties after a shock was investigated as a function of time by oscillatory measurement after destruction of the gel network for each product: HYMOVIS®, Synvisc®, and Durolane®. The stress cycle was repeated 6 times

Indication

HYMOVIS® ONE is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy or simple analgesics (e.g., acetaminophen).

Important Safety Information

HYMOVIS® ONE is contraindicated in patients with known hypersensitivity (allergy) to hyaluronate preparations or gram-positive bacterial proteins. Do not administer HYMOVIS® ONE to patients with infections or skin diseases in the area of the injection site or joint. The safety and effectiveness of HYMOVIS® ONE has not been established in pregnant women, nursing mothers, or children or for use in joints other than the knee, or concomitant use with other intra-articular (IA) injections. The effectiveness of repeat treatment cycles of HYMOVIS® ONE has not been established. No serious adverse events or pseudoseptic reactions were reported in the HYMOVIS® ONE clinical study. The adverse events experienced and reported in the HYMOVIS® ONE clinical study were joint swelling, metatarsalgia, neck pain and headache.

Rx Only. See package insert for full prescribing information including indications, contraindications, adverse events, warnings, precautions, and side effects.

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Hymovis® One

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References:
3. Bonnevie ED, Galesso D, Secchieri C, Bonassar LJ (2019) Frictional characterization of
injectable hyaluronic acids is more predictive of clinic outcomes than traditional rheological or
viscoelastic characterization. PLoS ONE 14(5): e0216702.
https://doi.org/10.1371/journal.pone.0216702
4. Finelli I, Chiessi E, Galesso D, Renier D, Paradossi G. A new viscosupplement based on
partially hydrophobic hyaluronic acid: a comparative study. Biorheology. 2011;48(5):263-275

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